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KMID : 0378020090520030020
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New Medical Journal
2009 Volume.52 No. 3 p.20 ~ p.25
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The Effects of Continuous Infusion of Ondansetron on Postoperative Nausea and Vomiting in Patients Receiving Intravenous-patient Controlled Analgesia Following Gynecological Surgery
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Bae Sang-Chul
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Abstract
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Background: The study was designed to determine the effectiveness of continuous infusion of ondansetron for the prevention of postoperative nausea and vomiting (PONV) in patients receiving intravnous-patient controlled analgesia (IV-PCA) follwing gynecological surgery.
Methods: One hundred and sixty patients ASA class 1 and 2 patients scheduled for gynecological surgery were randomized into four groups according to the method of ondansetron administration, placebo (n=40, group 1), ondansetron 8mg mixed to IV-PCA (n=40, group 2), ondansetron 4 mg IV before induction or after surgery in addition to 8 mg mixed to IV-PCA (n=40, group 3 or n=40, group 4). The incidence of nausea, vomiting, and side effects were recorded for 48 hr postoperatively.
Results: The incidence of nausea in group 1 (49 %) was significantly higher than in the other groups (group 2; 20%, group 3; 15%, group 4; 18%) (P＜0.05), and vomiting was one in group 1.
Conclusions: Continuous ondansetron infusion is effective at preventing PONV, but the effects of additional bolus injections to continuous infusion of ondansetron were not different from continuous infusion only.
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KEYWORD
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IV-PCA, Ondansetron, Postoperative nausea and vomiting (PONV)Background: The study was designed to determine the effectiveness of continuous infusion
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